7WGX

SARS-CoV-2 spike glycoprotein trimer in closed state after treatment with Cathepsin L

Summary for 7WGX

• Entry DOI: 10.2210/pdb7wgx/pdb
• EMDB information: 32491
• Descriptor: Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 3
• Total formula weight: 415063.57

Authors

Zhu, Y.,Tai, L.,Yin, G.,Sun, F. (deposition date: 2021-12-29, release date: 2023-01-04)

• Primary citation: Zhao, M.M.,Zhu, Y.,Zhang, L.,Zhong, G.,Tai, L.,Liu, S.,Yin, G.,Lu, J.,He, Q.,Li, M.J.,Zhao, R.X.,Wang, H.,Huang, W.,Fan, C.,Shuai, L.,Wen, Z.,Wang, C.,He, X.,Chen, Q.,Liu, B.,Xiong, X.,Bu, Z.,Wang, Y.,Sun, F.,Yang, J.K.; Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies; Cell Discov, 8:53-, 2022; DOI: 10.1038/s41421-022-00419-w

Experimental method

ELECTRON MICROSCOPY (3.5 Å)