7WGX

SARS-CoV-2 spike glycoprotein trimer in closed state after treatment with Cathepsin L

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Spike glycoprotein	polymer	1204	133657.0	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein
2	D, E, F, G, H...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	15	In PDB GlyTouCan (G42666HT)
3	A, B, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	27	Chemie (NAG)
4	A, B, C	3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid	non-polymer		584.7	3	Chemie (BLR)

Sequence modifications

A, B, C: 14 - 1211 (UniProt: P0DTC2)

PDB	External Database	Details
-	Pro 681	deletion
-	Arg 682	deletion
-	Arg 683	deletion
-	Ala 684	deletion
Gly 1212	-	expression tag
Ser 1213	-	expression tag
Gly 1214	-	expression tag
Arg 1215	-	expression tag
Glu 1216	-	expression tag
Asn 1217	-	expression tag
Leu 1218	-	expression tag
Tyr 1219	-	expression tag
Phe 1220	-	expression tag
Gln 1221	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	400971.0
Branched	Number of molecules	15
	Total formula weight	6366.0
Non-Polymers*	Number of molecules	30
	Total formula weight	7726.6
All*	Total formula weight	415063.6

*Water molecules are not included.