7W7Y
The crystal structure of human abl1 kinase domain in complex with ABL2-A5
Summary for 7W7Y
Entry DOI | 10.2210/pdb7w7y/pdb |
Descriptor | Tyrosine-protein kinase ABL1, 5-[3-(5-methanoyl-2-methoxy-4-oxidanyl-phenyl)-1~{H}-pyrrolo[2,3-b]pyridin-5-yl]-~{N},~{N}-dimethyl-pyridine-3-carboxamide (3 entities in total) |
Functional Keywords | abl1, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 64955.92 |
Authors | Zhu, C.,Zhang, Z.M. (deposition date: 2021-12-06, release date: 2022-04-27, Last modification date: 2023-11-29) |
Primary citation | Chen, P.,Sun, J.,Zhu, C.,Tang, G.,Wang, W.,Xu, M.,Xiang, M.,Zhang, C.J.,Zhang, Z.M.,Gao, L.,Yao, S.Q. Cell-Active, Reversible, and Irreversible Covalent Inhibitors That Selectively Target the Catalytic Lysine of BCR-ABL Kinase. Angew.Chem.Int.Ed.Engl., 61:e202203878-e202203878, 2022 Cited by PubMed: 35438229DOI: 10.1002/anie.202203878 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.20003021871 Å) |
Structure validation
Download full validation report