7VOD
Crystal structure of 5-HT2AR in complex with cariprazine
Summary for 7VOD
Entry DOI | 10.2210/pdb7vod/pdb |
Descriptor | 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, MAGNESIUM ION, CHOLESTEROL, ... (5 entities in total) |
Functional Keywords | gpcr, dopamine receptor, serotonin receptor, cariprazine, antipsychotic, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 44639.37 |
Authors | |
Primary citation | Chen, Z.,Fan, L.,Wang, H.,Yu, J.,Lu, D.,Qi, J.,Nie, F.,Luo, Z.,Liu, Z.,Cheng, J.,Wang, S. Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties. Nat.Neurosci., 25:39-49, 2022 Cited by PubMed: 34887590DOI: 10.1038/s41593-021-00971-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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