7VOD
Crystal structure of 5-HT2AR in complex with cariprazine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 | polymer | 376 | 41958.1 | 1 | UniProt (P28223) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB | Homo sapiens (human) | 5-HT-2,5-HT-2A,Serotonin receptor 2A,Cytochrome b-562 |
2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
3 | A | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) | |||
4 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 3 | Chemie (OLC) | |||
5 | A | 3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea | non-polymer | 427.4 | 1 | Chemie (7RU) |
Sequence modifications
A: 70 - 265 (UniProt: P28223)
A: 1001 - 1040 (UniProt: P0ABE7)
A: 1066 - 1106 (UniProt: P0ABE7)
A: 313 - 403 (UniProt: P28223)
PDB | External Database | Details |
---|---|---|
Gly 67 | - | expression tag |
Gly 68 | - | expression tag |
Thr 69 | - | expression tag |
Lys 162 | Ser 162 | engineered mutation |
Trp 164 | Met 164 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Trp 1007 | Met 29 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 1061 | - | linker |
Ser 1062 | - | linker |
Gly 1063 | - | linker |
Ser 1064 | - | linker |
Gly 1065 | - | linker |
Ile 1098 | Arg 120 | engineered mutation |
Ile 1102 | His 124 | engineered mutation |
Gly 1106 | Arg 128 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Asn 372 | Ser 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 41958.1 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2681.3 | |
All* | Total formula weight | 44639.4 |