7VM6
Crystal structure of uPA in complex with 6-amidino-2-naphthol
Summary for 7VM6
Entry DOI | 10.2210/pdb7vm6/pdb |
Descriptor | Urokinase-type plasminogen activator chain B, 6-oxidanylnaphthalene-2-carboximidamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | upa, serine protease, 6-amidino-2-naphthol, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 28406.27 |
Authors | Jiang, L.G.,Huang, M.D. (deposition date: 2021-10-07, release date: 2022-10-12, Last modification date: 2023-11-29) |
Primary citation | Zhou, Y.,Wu, J.,Xue, G.,Li, J.,Jiang, L.,Huang, M. Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat. Biophys.J., 121:3940-3949, 2022 Cited by PubMed: 36039386DOI: 10.1016/j.bpj.2022.08.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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