7UZR
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
Summary for 7UZR
Entry DOI | 10.2210/pdb7uzr/pdb |
Descriptor | Cyclic GMP-AMP synthase, Palindromic DNA18, [[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, ... (6 entities in total) |
Functional Keywords | complex, pppgpg, manganese, immune system, transferase-dna complex, transferase/dna |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 109426.26 |
Authors | Wu, S.,Gabelli, S.B.,Sohn, J. (deposition date: 2022-05-09, release date: 2023-05-10, Last modification date: 2024-05-22) |
Primary citation | Wu, S.,Gabelli, S.B.,Sohn, J. The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS Nat Commun, 15:4012-, 2024 Cited by DOI: 10.1038/s41467-024-48365-3PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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