7UZR
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Cyclic GMP-AMP synthase | polymer | 364 | 42640.3 | 2 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) In PDB | Mus musculus (house mouse) | cGAMP synthase,cGAS,m-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | E, F, I, J | Palindromic DNA18 | polymer | 18 | 5514.6 | 4 | synthetic construct | ||
| 3 | A, C | [[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | non-polymer | 868.4 | 2 | Chemie (OKR) | |||
| 4 | A, C | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | A, C | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 6 | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A, C: 147 - 507 (UniProt: Q8C6L5)
| PDB | External Database | Details |
|---|---|---|
| Gly 144 | - | expression tag |
| Thr 145 | - | expression tag |
| Gly 146 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 107338.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2087.3 | |
| All* | Total formula weight | 109426.3 |
