7UWP
Detergent-bound CYP51 from Acanthamoeba castellanii
Summary for 7UWP
Entry DOI | 10.2210/pdb7uwp/pdb |
Descriptor | sterol 14a-demethylase, PROTOPORPHYRIN IX CONTAINING FE, DODECYL-BETA-D-MALTOSIDE, ... (4 entities in total) |
Functional Keywords | cytochrome p450, cyp51, sterol 14 alpha- demethylase, sterol biosynthesis, oxidoreductase |
Biological source | Acanthamoeba castellanii |
Total number of polymer chains | 2 |
Total formula weight | 107148.85 |
Authors | Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (deposition date: 2022-05-03, release date: 2023-04-12, Last modification date: 2024-05-01) |
Primary citation | Hargrove, T.Y.,Lamb, D.C.,Wawrzak, Z.,Hull, M.,Kelly, S.L.,Guengerich, F.P.,Lepesheva, G.I. Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14-Demethylase as a Key Drug Target J.Med.Chem., 2024 |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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