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7UVR

Crystal structure of human ClpP protease in complex with TR-65

Summary for 7UVR
Entry DOI10.2210/pdb7uvr/pdb
DescriptorATP-dependent Clp protease proteolytic subunit, mitochondrial, 3-{[(10R)-4-[(4-chlorophenyl)methyl]-5-oxo-1,2,4,5,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-7(6H)-yl]methyl}benzonitrile (3 entities in total)
Functional Keywordsagonist, protease, degradation, apoptosis, cancer, hydrolase, hydrolase-agonist complex, hydrolase/agonist
Biological sourceHomo sapiens (human)
Total number of polymer chains7
Total formula weight172282.54
Authors
Mabanglo, M.F.,Houry, W.A. (deposition date: 2022-05-02, release date: 2023-01-11, Last modification date: 2023-10-25)
Primary citationMabanglo, M.F.,Wong, K.S.,Barghash, M.M.,Leung, E.,Chuang, S.H.W.,Ardalan, A.,Majaesic, E.M.,Wong, C.J.,Zhang, S.,Lang, H.,Karanewsky, D.S.,Iwanowicz, A.A.,Graves, L.M.,Iwanowicz, E.J.,Gingras, A.C.,Houry, W.A.
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Structure, 31:185-, 2023
Cited by
PubMed: 36586405
DOI: 10.1016/j.str.2022.12.002
PDB entries with the same primary citation
Experimental method
Structure validation

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