7UVM
Crystal structure of human ClpP protease in complex with TR-27
Summary for 7UVM
Entry DOI | 10.2210/pdb7uvm/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, mitochondrial, (10R)-4-[(4-chlorophenyl)methyl]-7-[(3-ethynylphenyl)methyl]-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one (3 entities in total) |
Functional Keywords | agonist, protease, degradation, apoptosis, hydrolase, hydrolase-agonist complex, hydrolase/agonist |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 7 |
Total formula weight | 172275.63 |
Authors | Mabanglo, M.F.,Houry, W.A. (deposition date: 2022-05-02, release date: 2023-01-11, Last modification date: 2023-10-25) |
Primary citation | Mabanglo, M.F.,Wong, K.S.,Barghash, M.M.,Leung, E.,Chuang, S.H.W.,Ardalan, A.,Majaesic, E.M.,Wong, C.J.,Zhang, S.,Lang, H.,Karanewsky, D.S.,Iwanowicz, A.A.,Graves, L.M.,Iwanowicz, E.J.,Gingras, A.C.,Houry, W.A. Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome. Structure, 31:185-, 2023 Cited by PubMed: 36586405DOI: 10.1016/j.str.2022.12.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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