7UVB
CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT021601
Summary for 7UVB
Entry DOI | 10.2210/pdb7uvb/pdb |
Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total) |
Functional Keywords | metalloprotein, globulin, oxygen transport |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 65379.99 |
Authors | Partridge, J.R.,Kaya, E.,Xu, Q.,Li, Z.,Strutt, S.C.,Cathers, B.E. (deposition date: 2022-04-29, release date: 2023-04-05, Last modification date: 2023-10-25) |
Primary citation | Dufu, K.,Alt, C.,Strutt, S.,Partridge, J.,Tang, T.,Siu, V.,Liao-Zou, H.,Rademacher, P.,Williams, A.T.,Muller, C.R.,Geng, X.,Pochron, M.P.,Dang, A.N.,Cabrales, P.,Li, Z.,Oksenberg, D.,Cathers, B.E. GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model. Br.J.Haematol., 202:173-183, 2023 Cited by PubMed: 36960712DOI: 10.1111/bjh.18771 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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