7UVB
CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT021601
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Hemoglobin subunit alpha | polymer | 141 | 15150.4 | 2 | UniProt (P69905) Pfam (PF00042) | Homo sapiens (human) | Alpha-globin,Hemoglobin alpha chain |
| 2 | B, D (B, D) | Hemoglobin subunit beta | polymer | 146 | 15860.2 | 2 | UniProt (P68871) Pfam (PF00042) | Homo sapiens (human) | Beta-globin,Hemoglobin beta chain |
| 3 | E, H, J, M (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 4 | F, I, K, N (A, B, C, D) | FORMYL GROUP | non-polymer | 30.0 | 4 | Chemie (FOR) | |||
| 5 | G, L (A, C) | 2-hydroxy-6-({(3S)-4-[2-(2-hydroxyethyl)pyridine-3-carbonyl]morpholin-3-yl}methoxy)benzaldehyde | non-polymer | 386.4 | 2 | Chemie (OHF) | |||
| 6 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
B, D: 1 - 146 (UniProt: P68871)
| PDB | External Database | Details |
|---|---|---|
| Val 6 | Glu 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62021.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3358.8 | |
| All* | Total formula weight | 65380.0 |
