7USG
BRD2-BD2 in complex with MDP5
Summary for 7USG
Entry DOI | 10.2210/pdb7usg/pdb |
Descriptor | Bromodomain-containing protein 2, (8M)-8-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(morpholin-4-yl)-4H-1-benzopyran-4-one, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | inhibitor, acetyllysine binding pocket, transcription, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 13568.54 |
Authors | Jayasinghe, T.D.,Ronning, D.R. (deposition date: 2022-04-25, release date: 2023-01-18, Last modification date: 2023-10-25) |
Primary citation | Sethi, B.,Kumar, V.,Jayasinghe, T.D.,Dong, Y.,Ronning, D.R.,Zhong, H.A.,Coulter, D.W.,Mahato, R.I. Targeting BRD4 and PI3K signaling pathways for the treatment of medulloblastoma. J Control Release, 354:80-90, 2023 Cited by PubMed: 36599397DOI: 10.1016/j.jconrel.2022.12.055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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