7UPX

Three RBD-down state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment (local refinement of the RBD and Fab variable domains)

Summary for 7UPX

Entry DOI	10.2210/pdb7upx/pdb
EMDB information	26677
Descriptor	Spike glycoprotein, SP1-77 Fab heavy chain, SP1-77 Fab light chain, ... (4 entities in total)
Functional Keywords	viral protein
Biological source	Severe acute respiratory syndrome coronavirus More
Total number of polymer chains	3
Total formula weight	218388.89
Authors	Zhang, J.,Luo, S.,Kreutzberger, A.,Kirchhausen, T.,Chen, B.,Haynes, B.,Alt, F. (deposition date: 2022-04-18, release date: 2022-08-10, Last modification date: 2023-08-23)
Primary citation	Luo, S.,Zhang, J.,Kreutzberger, A.J.B.,Eaton, A.,Edwards, R.J.,Jing, C.,Dai, H.Q.,Sempowski, G.D.,Cronin, K.,Parks, R.,Ye, A.Y.,Mansouri, K.,Barr, M.,Pishesha, N.,Williams, A.C.,Vieira Francisco, L.,Saminathan, A.,Peng, H.,Batra, H.,Bellusci, L.,Khurana, S.,Alam, S.M.,Montefiori, D.C.,Saunders, K.O.,Tian, M.,Ploegh, H.,Kirchhausen, T.,Chen, B.,Haynes, B.F.,Alt, F.W. An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Sci Immunol, 7:eadd5446-eadd5446, 2022 Cited by PubMed: 35951767 DOI: 10.1126/sciimmunol.add5446 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation