7UKL

Cryo-EM structure of Antibody 12-16 in complex with prefusion SARS-CoV-2 Spike glycoprotein

Summary for 7UKL

• Entry DOI: 10.2210/pdb7ukl/pdb
• EMDB information: 26583 26584
• Descriptor: 12-16 Fab Light Chain, Spike glycoprotein, 12-16 Fab Heavy Chain, ... (4 entities in total)
• Functional Keywords: neutralizing antibody, viral fusion protein, sars-cov-2, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 9
• Total formula weight: 513055.49

Authors

Casner, R.G.,Shapiro, L. (deposition date: 2022-04-01, release date: 2023-10-04, Last modification date: 2023-10-25)

• Primary citation: Liu, L.,Casner, R.G.,Guo, Y.,Wang, Q.,Iketani, S.,Chan, J.F.,Yu, J.,Dadonaite, B.,Nair, M.S.,Mohri, H.,Reddem, E.R.,Yuan, S.,Poon, V.K.,Chan, C.C.,Yuen, K.Y.,Sheng, Z.,Huang, Y.,Bloom, J.D.,Shapiro, L.,Ho, D.D.; Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking.; Immunity, 56:2442-, 2023; PubMed: 37776849; DOI: 10.1016/j.immuni.2023.09.003

Experimental method

ELECTRON MICROSCOPY (3.09 Å)