7UGW
M. tuberculosis DNA gyrase cleavage core bound to DNA and evybactin
Summary for 7UGW
| Entry DOI | 10.2210/pdb7ugw/pdb |
| Related PRD ID | PRD_002496 |
| Descriptor | DNA gyrase subunit A, DNA gyrase subunit B, DNA (46-MER), ... (5 entities in total) |
| Functional Keywords | topoisomerase, inhibitor, natural product, isomerase-antibiotic-dna complex, isomerase/antibiotic/dna |
| Biological source | Mycobacterium tuberculosis H37Rv More |
| Total number of polymer chains | 6 |
| Total formula weight | 183784.17 |
| Authors | Hauk, G.,Imai, Y.,Lewis, K.,Berger, J.M. (deposition date: 2022-03-25, release date: 2022-08-17, Last modification date: 2023-10-18) |
| Primary citation | Imai, Y.,Hauk, G.,Quigley, J.,Liang, L.,Son, S.,Ghiglieri, M.,Gates, M.F.,Morrissette, M.,Shahsavari, N.,Niles, S.,Baldisseri, D.,Honrao, C.,Ma, X.,Guo, J.J.,Berger, J.M.,Lewis, K. Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis. Nat.Chem.Biol., 18:1236-1244, 2022 Cited by PubMed: 35996001DOI: 10.1038/s41589-022-01102-7 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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