7TZH
Structure of human LAG3 domains 3-4 in complex with antibody single chain-variable fragment
Summary for 7TZH
Entry DOI | 10.2210/pdb7tzh/pdb |
Descriptor | scFvF7, Lymphocyte activation gene 3 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | immune checkpoint, cell surface, t cell, complex, antibody, ig-like fold, immunosuppressant |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 92020.60 |
Authors | Ming, Q.,Tran, T.H.,Luca, V.C. (deposition date: 2022-02-15, release date: 2022-05-11, Last modification date: 2023-10-18) |
Primary citation | Ming, Q.,Celias, D.P.,Wu, C.,Cole, A.R.,Singh, S.,Mason, C.,Dong, S.,Tran, T.H.,Amarasinghe, G.K.,Ruffell, B.,Luca, V.C. LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition. Nat.Immunol., 23:1031-1041, 2022 Cited by PubMed: 35761082DOI: 10.1038/s41590-022-01238-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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