7TNN
Complex GGNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)
Summary for 7TNN
Entry DOI | 10.2210/pdb7tnn/pdb |
EMDB information | 26011 26012 26013 26014 26015 26016 26017 |
Descriptor | Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera, GLUTAMIC ACID, CYCLOTHIAZIDE (3 entities in total) |
Functional Keywords | ampa, iglur, stargazin, cryo-em, complex, agonist, positive allosteric modulator, subconductance level, opening, gating, glutamate, membrane protein |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 4 |
Total formula weight | 463633.46 |
Authors | Yelshanskaya, M.V.,Sobolevsky, A.I. (deposition date: 2022-01-21, release date: 2022-04-20, Last modification date: 2022-05-18) |
Primary citation | Yelshanskaya, M.V.,Patel, D.S.,Kottke, C.M.,Kurnikova, M.G.,Sobolevsky, A.I. Opening of glutamate receptor channel to subconductance levels. Nature, 605:172-178, 2022 Cited by PubMed: 35444281DOI: 10.1038/s41586-022-04637-w PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.91 Å) |
Structure validation
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