7TGM
Crystal structure of HSC-AMS bound DesD, the desferrioxamine synthetase from the Streptomyces griseoflavus ferrimycin biosynthetic pathway
Summary for 7TGM
Entry DOI | 10.2210/pdb7tgm/pdb |
Descriptor | Desferrioxamine synthetase DesD, GLYCEROL, 4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoic acid, ... (8 entities in total) |
Functional Keywords | nrps-independent siderophore (nis) synthetase, iterative synthetase, amide ligase, adenylate-forming enzyme, ligase, inhibitor, ligase-inhibitor complex, ligase/inhibitor |
Biological source | Streptomyces griseoflavus |
Total number of polymer chains | 5 |
Total formula weight | 357175.32 |
Authors | Patel, K.D.,Gulick, A.M. (deposition date: 2022-01-07, release date: 2022-07-06, Last modification date: 2023-10-18) |
Primary citation | Yang, J.,Banas, V.S.,Patel, K.D.,Rivera, G.S.M.,Mydy, L.S.,Gulick, A.M.,Wencewicz, T.A. An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD. J.Biol.Chem., 298:102166-102166, 2022 Cited by PubMed: 35750210DOI: 10.1016/j.jbc.2022.102166 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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