Summary for 7TD9
Entry DOI | 10.2210/pdb7td9/pdb |
Related | 7TAB |
Descriptor | Isoform 4 of Transcription activator BRG1, 4-phenyl-5H-pyridazino[4,3-b]indol-3-amine (3 entities in total) |
Functional Keywords | bromodomain brg1 smarca4 inhibitor, protein binding, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 46093.57 |
Authors | Tang, Y.,Poy, F.,Taylor, A.M.,Cochran, A.G.,Bellon, S.F. (deposition date: 2021-12-30, release date: 2022-08-17, Last modification date: 2023-10-18) |
Primary citation | Taylor, A.M.,Bailey, C.,Belmont, L.D.,Campbell, R.,Cantone, N.,Cote, A.,Crawford, T.D.,Cummings, R.,DeMent, K.,Duplessis, M.,Flynn, M.,Good, A.C.,Huang, H.R.,Joshi, S.,Leblanc, Y.,Murray, J.,Nasveschuk, C.G.,Neiss, A.,Poy, F.,Romero, F.A.,Sandy, P.,Tang, Y.,Tsui, V.,Zawadzke, L.,Sims 3rd, R.J.,Audia, J.E.,Bellon, S.F.,Magnuson, S.R.,Albrecht, B.K.,Cochran, A.G. GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. J.Med.Chem., 65:11177-11186, 2022 Cited by PubMed: 35930799DOI: 10.1021/acs.jmedchem.2c00662 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
Download full validation report