7T9N
M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure)
Summary for 7T9N
Entry DOI | 10.2210/pdb7t9n/pdb |
EMDB information | 25763 |
Descriptor | M22 Fab light chain, M22 Fab heavy chain, Nanobody 35, ... (9 entities in total) |
Functional Keywords | g protein-coupled receptor, thyrotropin receptor, thyroid, m22, autoantibody, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 7 |
Total formula weight | 227413.69 |
Authors | Faust, B.,Cheng, Y.,Manglik, A. (deposition date: 2021-12-19, release date: 2022-08-03, Last modification date: 2022-10-05) |
Primary citation | Faust, B.,Billesbolle, C.B.,Suomivuori, C.M.,Singh, I.,Zhang, K.,Hoppe, N.,Pinto, A.F.M.,Diedrich, J.K.,Muftuoglu, Y.,Szkudlinski, M.W.,Saghatelian, A.,Dror, R.O.,Cheng, Y.,Manglik, A. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609:846-853, 2022 Cited by PubMed: 35940205DOI: 10.1038/s41586-022-05159-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
Download full validation report