7T6X
Cryo-EM structure of full-length hepatitis C virus E1E2 glycoprotein in complex with AR4A, AT12009, and IGH505 Fabs
Summary for 7T6X
Entry DOI | 10.2210/pdb7t6x/pdb |
EMDB information | 25730 |
Descriptor | Envelope glycoprotein E2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total) |
Functional Keywords | hepatitis c virus, e1e2, viral protein-immune system complex, antibody-antigen complex, viral protein/immune system |
Biological source | Hepacivirus C More |
Total number of polymer chains | 8 |
Total formula weight | 253883.93 |
Authors | Torrents de la Pena, A.,Ward, A.B.,Eshun-Wilson, L.,Lander, G.C. (deposition date: 2021-12-14, release date: 2022-11-02) |
Primary citation | Torrents de la Pena, A.,Sliepen, K.,Eshun-Wilson, L.,Newby, M.L.,Allen, J.D.,Zon, I.,Koekkoek, S.,Chumbe, A.,Crispin, M.,Schinkel, J.,Lander, G.C.,Sanders, R.W.,Ward, A.B. Structure of the hepatitis C virus E1E2 glycoprotein complex. Science, 378:263-269, 2022 Cited by PubMed: 36264808DOI: 10.1126/science.abn9884 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.83 Å) |
Structure validation
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