7T6X
Cryo-EM structure of full-length hepatitis C virus E1E2 glycoprotein in complex with AR4A, AT12009, and IGH505 Fabs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (U) | Envelope glycoprotein E2 | polymer | 363 | 40156.7 | 1 | UniProt (A0A159UHX2) | Hepacivirus C | |
| 2 | B (H) | AR4A Fab, heavy chain | polymer | 277 | 29808.5 | 1 | Homo sapiens (Human) | ||
| 3 | C (L) | AR4A, kappa light chain | polymer | 233 | 25290.2 | 1 | Homo sapiens (Human) | ||
| 4 | D (A) | IGH505, heavy chain | polymer | 475 | 52277.0 | 1 | Homo sapiens (Human) | ||
| 5 | E (B) | IGH505, lambda light chain | polymer | 235 | 24974.8 | 1 | Homo sapiens (Human) | ||
| 6 | F (D) | AT12009 crossMab, light kappa chain | polymer | 229 | 24014.1 | 1 | Homo sapiens (Human) | ||
| 7 | G (C) | AT12009 CrossMab, heavy chain | polymer | 274 | 29151.7 | 1 | Homo sapiens (Human) | ||
| 8 | H (E) | Envelope glycoprotein E1 | polymer | 192 | 20956.3 | 1 | UniProt (A0A159UHX2) UniProt (by SIFTS) (Q98UN8) | Hepacivirus C | |
| 9 | I, N (F, M) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 10 | J, K, M, Q (G, I, K, P) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 11 | L (J) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G94626GC) | |||
| 12 | O, P (N, O) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 13 | R, S, T, U, V... (U, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
U: 384 - 746 (UniProt: A0A159UHX2)
| PDB | External Database | Details |
|---|---|---|
| Ile 442 | Phe 274 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 246629.2 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 5927.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1327.2 | |
| All* | Total formula weight | 253883.9 |
