7T6X
Cryo-EM structure of full-length hepatitis C virus E1E2 glycoprotein in complex with AR4A, AT12009, and IGH505 Fabs
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | U | Envelope glycoprotein E2 | polymer | 363 | 40156.7 | 1 | UniProt (A0A159UHX2) Pfam (PF01560) In PDB | Hepacivirus C | |
2 | H | AR4A Fab, heavy chain | polymer | 277 | 29808.5 | 1 | Homo sapiens (Human) | ||
3 | L | AR4A, kappa light chain | polymer | 233 | 25290.2 | 1 | Homo sapiens (Human) | ||
4 | A | IGH505, heavy chain | polymer | 475 | 52277.0 | 1 | Homo sapiens (Human) | ||
5 | B | IGH505, lambda light chain | polymer | 235 | 24974.8 | 1 | Homo sapiens (Human) | ||
6 | D | AT12009 crossMab, light kappa chain | polymer | 229 | 24014.1 | 1 | Homo sapiens (Human) | ||
7 | C | AT12009 CrossMab, heavy chain | polymer | 274 | 29151.7 | 1 | Homo sapiens (Human) | ||
8 | E | Envelope glycoprotein E1 | polymer | 192 | 20956.3 | 1 | UniProt (A0A159UHX2) Pfam (PF01539) UniProt (by SIFTS) (Q98UN8) In PDB | Hepacivirus C | |
9 | F, M | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
10 | G, I, K, P | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
11 | J | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G94626GC) | |||
12 | N, O | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
13 | U, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
U: 384 - 746 (UniProt: A0A159UHX2)
PDB | External Database | Details |
---|---|---|
Ile 442 | Phe 274 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 246629.2 | |
Branched | Number of molecules | 9 |
Total formula weight | 5927.4 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1327.2 | |
All* | Total formula weight | 253883.9 |