7T1G
Crystal structure of CAB1 Pantothenate Kinase from Saccharomyces cerevisiae in complex with compound YU385595
Summary for 7T1G
Entry DOI | 10.2210/pdb7t1g/pdb |
Related | 6UJ5 7T1H 7T1I |
Descriptor | Pantothenate kinase CAB1, (8S)-N~2~-[(4-tert-butylphenyl)methyl]-N~7~,N~7~-dimethyl-5-[(morpholin-4-yl)methyl][1,2,4]triazolo[1,5-a]pyrimidine-2,7-diamine (3 entities in total) |
Functional Keywords | kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Saccharomyces cerevisiae S288C |
Total number of polymer chains | 2 |
Total formula weight | 84371.93 |
Authors | Gihaz, S.,Ben Mamoun, C. (deposition date: 2021-12-01, release date: 2022-10-05, Last modification date: 2023-10-18) |
Primary citation | Gihaz, S.,Gareiss, P.,Choi, J.Y.,Renard, I.,Pal, A.C.,Surovsteva, Y.,Chiu, J.E.,Thekkiniath, J.,Plummer, M.,Hungerford, W.,Montgomery, M.L.,Hosford, A.,Adams, E.M.,Lightfoot, J.D.,Fox 3rd, D.,Ojo, K.K.,Staker, B.L.,Fuller, K.,Ben Mamoun, C. High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development. Structure, 30:1494-, 2022 Cited by PubMed: 36167065DOI: 10.1016/j.str.2022.09.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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