7SHP

Crystal structure of hSTING in complex with c[2',3'-(ribo-2'-G, xylo-3'-A)-MP](RJ244)

Summary for 7SHP

• Entry DOI: 10.2210/pdb7shp/pdb
• Descriptor: Stimulator of interferon genes protein, (2S,5R,7R,8R,10S,12aR,14R,15R,15aR,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione (3 entities in total)
• Functional Keywords: sting, agonist, cgamp analogs, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 87445.45

Authors

Xie, W.,Lama, L.,Yang, X.J.,Kuryavyi, V.,Nudelman, I.,Glickman, J.F.,Jones, R.A.,Tuschl, T.,Patel, D.J. (deposition date: 2021-10-11, release date: 2022-10-19, Last modification date: 2023-10-18)

• Primary citation: Xie, W.,Lama, L.,Yang, X.,Kuryavyi, V.,Bhattacharya, S.,Nudelman, I.,Yang, G.,Ouerfelli, O.,Glickman, J.F.,Jones, R.A.,Tuschl, T.,Patel, D.J.; Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.; Cell Chem Biol, 2023; PubMed: 37536341; DOI: 10.1016/j.chembiol.2023.07.002

Experimental method

X-RAY DIFFRACTION (2.2 Å)