7SHP
Crystal structure of hSTING in complex with c[2',3'-(ribo-2'-G, xylo-3'-A)-MP](RJ244)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Stimulator of interferon genes protein | polymer | 188 | 21524.2 | 4 | UniProt (Q86WV6) Pfam (PF15009) | Homo sapiens (Human) | hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173 |
| 2 | E, F (A, D) | (2S,5R,7R,8R,10S,12aR,14R,15R,15aR,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione | non-polymer | 674.4 | 2 | Chemie (9UR) | |||
| 3 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 184 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 155 - 341 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Ser 154 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 86096.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1348.8 | |
| All* | Total formula weight | 87445.5 |
