7SB7
Crystal structure of T. brucei hypoxanthine guanine phosphoribosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate
Summary for 7SB7
| Entry DOI | 10.2210/pdb7sb7/pdb |
| Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid (3 entities in total) |
| Functional Keywords | inhibitor, complex, phosphonate, purine, transferase |
| Biological source | Trypanosoma brucei brucei |
| Total number of polymer chains | 2 |
| Total formula weight | 49330.04 |
| Authors | Guddat, L.W.,Keough, D.T. (deposition date: 2021-09-24, release date: 2022-03-02, Last modification date: 2023-10-18) |
| Primary citation | Klejch, T.,Keough, D.T.,King, G.,Dolezelova, E.,Cesnek, M.,Budesinsky, M.,Zikova, A.,Janeba, Z.,Guddat, L.W.,Hockova, D. Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases. J.Med.Chem., 65:4030-4057, 2022 Cited by PubMed: 35175749DOI: 10.1021/acs.jmedchem.1c01881 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.64716619036 Å) |
Structure validation
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