7SB7

Crystal structure of T. brucei hypoxanthine guanine phosphoribosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Hypoxanthine-guanine phosphoribosyltransferase	polymer	216	24221.8	2	UniProt (Q07010) Pfam (PF00156)	Trypanosoma brucei brucei	HGPRT,HGPRTase
2	C, D (A, B)	({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid	non-polymer		443.2	2	Chemie (8QI)
3	E, F (A, B)	water	water		18.0	70	Chemie (HOH)

Sequence modifications

A, B: 1 - 210 (UniProt: Q07010)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48443.6
Non-Polymers*	Number of molecules	2
	Total formula weight	886.5
All*	Total formula weight	49330.0

*Water molecules are not included.