7RZ4
Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK 200775
Summary for 7RZ4
Entry DOI | 10.2210/pdb7rz4/pdb |
EMDB information | 24750 |
Descriptor | Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | ampa receptor, ion channel, neurotransmission, synapse, tarp gamma-5, membrane protein |
Biological source | Rattus norvegicus (Rat) |
Total number of polymer chains | 4 |
Total formula weight | 485484.75 |
Authors | Gangwar, S.P.,Klykov, O.V.,Yelshanskaya, M.V.,Sobolevsky, A.I. (deposition date: 2021-08-27, release date: 2021-10-27, Last modification date: 2022-02-16) |
Primary citation | Klykov, O.,Gangwar, S.P.,Yelshanskaya, M.V.,Yen, L.,Sobolevsky, A.I. Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L. Mol.Cell, 81:4771-4783.e7, 2021 Cited by PubMed: 34678168DOI: 10.1016/j.molcel.2021.09.030 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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