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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7RZ4

Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK 200775

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)		Glutamate receptor 2polymer1038116018.04UniProt (P19491)
Pfam (PF01094)
Pfam (PF10613)
Pfam (PF00060)		Rattus norvegicus (Rat)GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2DA, E, M, U
(D, A, B, C)		{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acidnon-polymer409.34Chemie (ZK1)
3EA, F, N, V
(D, A, B, C)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.24Chemie (NAG)
4AA, BA, CA, FA, G...
(C, D, A, B)		1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINEnon-polymer787.124Chemie (PCW)
Sequence modifications
A, B, C, D: 10 - 826 (UniProt: P19491)
PDBExternal DatabaseDetails
Glu 241Asn 256conflict
Leu 382Val 397conflict
-Leu 399deletion
-Thr 400deletion
-Glu 401deletion
-Leu 402deletion
-Pro 403deletion
-Ser 404deletion
Glu 384Gly 405conflict
Asp 385Asn 406conflict
Gln 392Asn 413conflict
Thr 744Asn 765conflict
Pro 745Ala 766conflict
Ser 754Asn 775conflict
Val 758Leu 779conflict
Ala 775Ser 796conflict
Lys 776Gly 797conflict
Asp 777Gly 798conflict
Ser 778Gly 799conflict
Gly 779Asp 800conflict
Gly 827-expression tag
Thr 828-expression tag
Gly 829-expression tag
Ser 830-expression tag
Ala 831-expression tag
Cys 832-expression tag
Gly 833-expression tag
Arg 834-expression tag
Lys 835-expression tag
Ala 836-expression tag
Leu 837-expression tag
Thr 838-expression tag
Leu 839-expression tag
Leu 840-expression tag
Ser 841-expression tag
Ser 842-expression tag
Val 843-expression tag
Phe 844-expression tag
Ala 845-expression tag
Val 846-expression tag
Cys 847-expression tag
Gly 848-expression tag
Leu 849-expression tag
Gly 850-expression tag
Leu 851-expression tag
Leu 852-expression tag
Gly 853-expression tag
Ile 854-expression tag
Ala 855-expression tag
Val 856-expression tag
Ser 857-expression tag
Thr 858-expression tag
Asp 859-expression tag
Tyr 860-expression tag
Trp 861-expression tag
Leu 862-expression tag
Tyr 863-expression tag
Leu 864-expression tag
Glu 865-expression tag
Glu 866-expression tag
Gly 867-expression tag
Ile 868-expression tag
Ile 869-expression tag
Leu 870-expression tag
Pro 871-expression tag
Gln 872-expression tag
Asn 873-expression tag
Gln 874-expression tag
Ser 875-expression tag
Thr 876-expression tag
Glu 877-expression tag
Val 878-expression tag
Lys 879-expression tag
Met 880-expression tag
Ser 881-expression tag
Leu 882-expression tag
His 883-expression tag
Ser 884-expression tag
Gly 885-expression tag
Leu 886-expression tag
Trp 887-expression tag
Arg 888-expression tag
Val 889-expression tag
Cys 890-expression tag
Phe 891-expression tag
Leu 892-expression tag
Ala 893-expression tag
Gly 894-expression tag
Glu 895-expression tag
Glu 896-expression tag
Arg 897-expression tag
Gly 898-expression tag
Arg 899-expression tag
Cys 900-expression tag
Phe 901-expression tag
Thr 902-expression tag
Ile 903-expression tag
Glu 904-expression tag
Tyr 905-expression tag
Val 906-expression tag
Met 907-expression tag
Pro 908-expression tag
Met 909-expression tag
Asn 910-expression tag
Ser 911-expression tag
Gln 912-expression tag
Met 913-expression tag
Thr 914-expression tag
Ser 915-expression tag
Glu 916-expression tag
Ser 917-expression tag
Thr 918-expression tag
Val 919-expression tag
Asn 920-expression tag
Val 921-expression tag
Leu 922-expression tag
Lys 923-expression tag
Met 924-expression tag
Ile 925-expression tag
Arg 926-expression tag
Ser 927-expression tag
Ala 928-expression tag
Thr 929-expression tag
Pro 930-expression tag
Phe 931-expression tag
Pro 932-expression tag
Leu 933-expression tag
Val 934-expression tag
Ser 935-expression tag
Leu 936-expression tag
Phe 937-expression tag
Phe 938-expression tag
Met 939-expression tag
Phe 940-expression tag
Ile 941-expression tag
Gly 942-expression tag
Phe 943-expression tag
Ile 944-expression tag
Leu 945-expression tag
Ser 946-expression tag
Asn 947-expression tag
Ile 948-expression tag
Gly 949-expression tag
His 950-expression tag
Ile 951-expression tag
Arg 952-expression tag
Pro 953-expression tag
His 954-expression tag
Arg 955-expression tag
Thr 956-expression tag
Ile 957-expression tag
Leu 958-expression tag
Ala 959-expression tag
Phe 960-expression tag
Val 961-expression tag
Ser 962-expression tag
Gly 963-expression tag
Ile 964-expression tag
Phe 965-expression tag
Phe 966-expression tag
Ile 967-expression tag
Leu 968-expression tag
Ser 969-expression tag
Gly 970-expression tag
Leu 971-expression tag
Ser 972-expression tag
Leu 973-expression tag
Val 974-expression tag
Val 975-expression tag
Gly 976-expression tag
Leu 977-expression tag
Val 978-expression tag
Leu 979-expression tag
Tyr 980-expression tag
Ile 981-expression tag
Ser 982-expression tag
Ser 983-expression tag
Ile 984-expression tag
Asn 985-expression tag
Asp 986-expression tag
Glu 987-expression tag
Met 988-expression tag
Leu 989-expression tag
Asn 990-expression tag
Arg 991-expression tag
Thr 992-expression tag
Lys 993-expression tag
Asp 994-expression tag
Ala 995-expression tag
Glu 996-expression tag
Thr 997-expression tag
Tyr 998-expression tag
Phe 999-expression tag
Asn 1000-expression tag
Tyr 1001-expression tag
Lys 1002-expression tag
Tyr 1003-expression tag
Gly 1004-expression tag
Trp 1005-expression tag
Ser 1006-expression tag
Phe 1007-expression tag
Ala 1008-expression tag
Phe 1009-expression tag
Ala 1010-expression tag
Ala 1011-expression tag
Ile 1012-expression tag
Ser 1013-expression tag
Phe 1014-expression tag
Leu 1015-expression tag
Leu 1016-expression tag
Thr 1017-expression tag
Glu 1018-expression tag
Ser 1019-expression tag
Ala 1020-expression tag
Gly 1021-expression tag
Val 1022-expression tag
Met 1023-expression tag
Ser 1024-expression tag
Val 1025-expression tag
Tyr 1026-expression tag
Leu 1027-expression tag
Phe 1028-expression tag
Met 1029-expression tag
Lys 1030-expression tag
Arg 1031-expression tag
Tyr 1032-expression tag
Thr 1033-expression tag
Ala 1034-expression tag
Glu 1035-expression tag
Thr 1036-expression tag
Gly 1037-expression tag
Gly 1038-expression tag
Leu 1039-expression tag
Val 1040-expression tag
Pro 1041-expression tag
Arg 1042-expression tag
Gly 1043-expression tag
Ser 1044-expression tag
Ala 1045-expression tag
Ala 1046-expression tag
Ala 1047-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight464072.0
Non-Polymers*Number of molecules32
Total formula weight21412.8
All*Total formula weight485484.8
*Water molecules are not included.

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PDB entries from 2024-11-06

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