7RWQ
Crystal Structure of BPTF bromodomain in complex with 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-6-yl)amino]pyridazin-3(2H)-one
Summary for 7RWQ
Entry DOI | 10.2210/pdb7rwq/pdb |
Descriptor | Nucleosome-remodeling factor subunit BPTF, 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-6-yl)amino]pyridazin-3(2H)-one, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | brd4, gene regulation, gene regulation-inhibitor complex, gene regulation/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15739.25 |
Authors | Zahid, H.,Buchholz, C.,Johnson, J.A.,Shi, K.,Aihara, H.,Pomerantz, W.C.K. (deposition date: 2021-08-20, release date: 2022-08-24, Last modification date: 2023-10-18) |
Primary citation | Zahid, H.,Buchholz, C.R.,Singh, M.,Ciccone, M.F.,Chan, A.,Nithianantham, S.,Shi, K.,Aihara, H.,Fischer, M.,Schonbrunn, E.,Dos Santos, C.O.,Landry, J.W.,Pomerantz, W.C.K. New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64:13902-13917, 2021 Cited by PubMed: 34515477DOI: 10.1021/acs.jmedchem.1c01294 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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