7RWQ
Crystal Structure of BPTF bromodomain in complex with 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-6-yl)amino]pyridazin-3(2H)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nucleosome-remodeling factor subunit BPTF | polymer | 131 | 15408.4 | 1 | UniProt (Q12830) Pfam (PF00439) | Homo sapiens (Human) | Bromodomain and PHD finger-containing transcription factor,Fetal Alz-50 clone 1 protein,Fetal Alzheimer antigen |
| 2 | B (A) | 4-chloro-2-methyl-5-[(1,2,3,4-tetrahydroisoquinolin-6-yl)amino]pyridazin-3(2H)-one | non-polymer | 290.7 | 1 | Chemie (7XE) | |||
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D (A) | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A: 2791 - 2911 (UniProt: Q12830)
| PDB | External Database | Details |
|---|---|---|
| Gly 2781 | - | expression tag |
| Thr 2782 | - | expression tag |
| Glu 2783 | - | expression tag |
| Asn 2784 | - | expression tag |
| Leu 2785 | - | expression tag |
| Tyr 2786 | - | expression tag |
| Phe 2787 | - | expression tag |
| Gln 2788 | - | expression tag |
| Ser 2789 | - | expression tag |
| Met 2790 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15408.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 330.8 | |
| All* | Total formula weight | 15739.2 |
