7RPV

Crystal structure of affinity-enhancing and catalytically inactive ACE2 in complex with SARS-CoV-2 RBD

Summary for 7RPV

Entry DOI	10.2210/pdb7rpv/pdb
Descriptor	Processed angiotensin-converting enzyme 2, Spike protein S1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	sars-cov-2, receptor binding domain, engineered human ace2, enhanced affinity, catalytic-null, zinc binding site, hydrolase-viral protein complex, hydrolase/viral protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	380059.28
Authors	Chen, Y.,Tolbert, D.W.,Pazgier, M. (deposition date: 2021-08-04, release date: 2021-12-15, Last modification date: 2023-10-18)
Primary citation	Chen, Y.,Sun, L.,Ullah, I.,Beaudoin-Bussieres, G.,Anand, S.P.,Hederman, A.P.,Tolbert, W.D.,Sherburn, R.,Nguyen, D.N.,Marchitto, L.,Ding, S.,Wu, D.,Luo, Y.,Gottumukkala, S.,Moran, S.,Kumar, P.,Piszczek, G.,Mothes, W.,Ackerman, M.E.,Finzi, A.,Uchil, P.D.,Gonzalez, F.J.,Pazgier, M. Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities. Biorxiv, 2021 Cited by PubMed: 34845451 DOI: 10.1101/2021.11.24.469776 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.54 Å)

Structure validation