7RPV
Crystal structure of affinity-enhancing and catalytically inactive ACE2 in complex with SARS-CoV-2 RBD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, B, C, D) | Processed angiotensin-converting enzyme 2 | polymer | 597 | 69120.6 | 4 | UniProt (Q9BYF1) Pfam (PF01401) | Homo sapiens (Human) | |
| 2 | B, D, F, H (E, F, G, H) | Spike protein S1 | polymer | 218 | 24501.6 | 4 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | |
| 3 | AA, BA, DA, EA, FA... (C, D, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 24 | Chemie (NAG) | |||
| 4 | CA, JA, O, V (C, D, A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | KA (D) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 19 - 615 (UniProt: Q9BYF1)
| PDB | External Database | Details |
|---|---|---|
| Phe 79 | Leu 79 | engineered mutation |
| Tyr 82 | Met 82 | engineered mutation |
| Tyr 325 | Gln 325 | engineered mutation |
| Ala 374 | His 374 | engineered mutation |
| Ala 378 | His 378 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 374488.6 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 5570.6 | |
| All* | Total formula weight | 380059.3 |
