7RIA
Griffithsin variant Y28A/Y68A/Y110A
Summary for 7RIA
Entry DOI | 10.2210/pdb7ria/pdb |
Descriptor | Griffithsin, alpha-D-mannopyranose, SULFATE ION, ... (4 entities in total) |
Functional Keywords | lectin, mannose binding protein, hiv inhibitor, c3 pseudosymmetry, carbohydrate binding sites, sugar binding protein |
Biological source | Griffithsia sp. (strain Q66D336) (Red alga) |
Total number of polymer chains | 2 |
Total formula weight | 30356.68 |
Authors | Zhao, G.,Sun, J.,Bewley, C.A. (deposition date: 2021-07-19, release date: 2022-05-18, Last modification date: 2023-10-25) |
Primary citation | Sun, J.,Zhao, G.,Bylund, T.,Lee, M.,Adibhatla, S.,Kwong, P.D.,Chuang, G.Y.,Rawi, R.,Bewley, C.A. C 3 -Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity. Acs Chem.Biol., 17:1450-1459, 2022 Cited by PubMed: 35537058DOI: 10.1021/acschembio.1c00990 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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