7RB7
Room temperature structure of hAChE in complex with substrate analog 4K-TMA and MMB4 oxime
Summary for 7RB7
Entry DOI | 10.2210/pdb7rb7/pdb |
Descriptor | Acetylcholinesterase, 4,4-DIHYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM, 1,1'-methylenebis{4-[(E)-(hydroxyimino)methyl]pyridin-1-ium}, ... (4 entities in total) |
Functional Keywords | acetylcholine esterase, serine hydrolase, tetrahedral intermediate, oxime reactivator, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 121417.01 |
Authors | Kovalevsky, A.,Gerlits, O.,Radic, Z. (deposition date: 2021-07-05, release date: 2021-09-22, Last modification date: 2023-10-18) |
Primary citation | Gerlits, O.,Blakeley, M.P.,Keen, D.A.,Radic, Z.,Kovalevsky, A. Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure Curr Res Struct Biol, 3:206-215, 2021 Cited by DOI: 10.1016/j.crstbi.2021.08.003PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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