7RB7

Room temperature structure of hAChE in complex with substrate analog 4K-TMA and MMB4 oxime

Summary for 7RB7

• Entry DOI: 10.2210/pdb7rb7/pdb
• Descriptor: Acetylcholinesterase, 4,4-DIHYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM, 1,1'-methylenebis{4-[(E)-(hydroxyimino)methyl]pyridin-1-ium}, ... (4 entities in total)
• Functional Keywords: acetylcholine esterase, serine hydrolase, tetrahedral intermediate, oxime reactivator, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 121417.01

Authors

Kovalevsky, A.,Gerlits, O.,Radic, Z. (deposition date: 2021-07-05, release date: 2021-09-22, Last modification date: 2024-11-06)

• Primary citation: Gerlits, O.,Blakeley, M.P.,Keen, D.A.,Radic, Z.,Kovalevsky, A.; Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure; Curr Res Struct Biol, 3:206-215, 2021; DOI: 10.1016/j.crstbi.2021.08.003

Experimental method

X-RAY DIFFRACTION (2.6 Å)