7R9L
Crystal structure of HPK1 in complex with compound 2
Summary for 7R9L
Entry DOI | 10.2210/pdb7r9l/pdb |
Descriptor | Hematopoietic progenitor kinase, 2-amino-N,N-dimethyl-5-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide (3 entities in total) |
Functional Keywords | kinase, inhibitor, map4k1, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33400.73 |
Authors | Wu, P.,Lehoux, I.,Wang, W. (deposition date: 2021-06-29, release date: 2022-01-05, Last modification date: 2023-10-18) |
Primary citation | Chan, B.K.,Seward, E.,Lainchbury, M.,Brewer, T.F.,An, L.,Blench, T.,Cartwright, M.W.,Chan, G.K.Y.,Choo, E.F.,Drummond, J.,Elliott, R.L.,Gancia, E.,Gazzard, L.,Hu, B.,Jones, G.E.,Luo, X.,Madin, A.,Malhotra, S.,Moffat, J.G.,Pang, J.,Salphati, L.,Sneeringer, C.J.,Stivala, C.E.,Wei, B.,Wang, W.,Wu, P.,Heffron, T.P. Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). Acs Med.Chem.Lett., 13:84-91, 2022 Cited by PubMed: 35059127DOI: 10.1021/acsmedchemlett.1c00473 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.332 Å) |
Structure validation
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