7R9L
Crystal structure of HPK1 in complex with compound 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Hematopoietic progenitor kinase | polymer | 297 | 33120.4 | 1 | UniProt (Q92918) Pfam (PF00069) In PDB | Homo sapiens (Human) | HKP1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEKKK 1 |
| 2 | A | 2-amino-N,N-dimethyl-5-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide | non-polymer | 280.3 | 1 | Chemie (2YE) | |||
| 3 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 2 - 293 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Ala 171 | Ser 171 | conflict |
| Gly 294 | - | expression tag |
| Asn 295 | - | expression tag |
| Ser 296 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33120.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 280.3 | |
| All* | Total formula weight | 33400.7 |
