7Q6W
Crystal structure of the bromodomain of ATAD2 with triazolopyridazine (cpd 22)
Summary for 7Q6W
Entry DOI | 10.2210/pdb7q6w/pdb |
Descriptor | ATPase family AAA domain-containing protein 2, SULFATE ION, (1R,9S)-13-[[3-methyl-8-[(1-methylpiperidin-4-yl)amino]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]carbonyl]-11,13-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4,6-trien-10-one, ... (4 entities in total) |
Functional Keywords | bromodomain, epigenetics, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16202.23 |
Authors | Patel, S.J.,Winter-Holt, J.J. (deposition date: 2021-11-09, release date: 2022-01-19, Last modification date: 2024-05-01) |
Primary citation | Winter-Holt, J.J.,Bardelle, C.,Chiarparin, E.,Dale, I.L.,Davey, P.R.J.,Davies, N.L.,Denz, C.,Fillery, S.M.,Guerot, C.M.,Han, F.,Hughes, S.J.,Kulkarni, M.,Liu, Z.,Milbradt, A.,Moss, T.A.,Niu, H.,Patel, J.,Rabow, A.A.,Schimpl, M.,Shi, J.,Sun, D.,Yang, D.,Guichard, S. Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models. J.Med.Chem., 65:3306-3331, 2022 Cited by PubMed: 35133824DOI: 10.1021/acs.jmedchem.1c01871 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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