7Q6H
HUMAN JAK3 KINASE DOMAIN WITH 1-(4-((2-((1-methyl-1H-pyrazol-4-yl)amino)quinazolin-8-yl)amino)piperidin-1-yl)ethan-1-one
This is a non-PDB format compatible entry.
Summary for 7Q6H
Entry DOI | 10.2210/pdb7q6h/pdb |
Descriptor | Tyrosine-protein kinase JAK3, 1-[4-[[2-[(1-methylpyrazol-4-yl)amino]quinazolin-8-yl]amino]piperidin-1-yl]ethanone, SULFATE ION, ... (5 entities in total) |
Functional Keywords | inhibitor, jak3, kinase, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37774.99 |
Authors | Chung, C. (deposition date: 2021-11-07, release date: 2022-02-02, Last modification date: 2024-05-01) |
Primary citation | Wellaway, C.R.,Baldwin, I.R.,Bamborough, P.,Barker, D.,Bartholomew, M.A.,Chung, C.W.,Dumpelfeld, B.,Evans, J.P.,Fazakerley, N.J.,Homes, P.,Keeling, S.P.,Lewell, X.Q.,McNab, F.W.,Morley, J.,Needham, D.,Neu, M.,van Oosterhout, A.J.M.,Pal, A.,Reinhard, F.B.M.,Rianjongdee, F.,Robertson, C.M.,Rowland, P.,Shah, R.R.,Sherriff, E.B.,Sloan, L.A.,Teague, S.,Thomas, D.A.,Wellaway, N.,Wojno-Picon, J.,Woolven, J.M.,Coe, D.M. Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism. J.Med.Chem., 65:633-664, 2022 Cited by PubMed: 34928601DOI: 10.1021/acs.jmedchem.1c01765 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.749 Å) |
Structure validation
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