7Q6H
HUMAN JAK3 KINASE DOMAIN WITH 1-(4-((2-((1-methyl-1H-pyrazol-4-yl)amino)quinazolin-8-yl)amino)piperidin-1-yl)ethan-1-one
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | AAA | Tyrosine-protein kinase JAK3 | polymer | 327 | 37177.3 | 1 | UniProt (P52333) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK |
| 2 | AAA | 1-[4-[[2-[(1-methylpyrazol-4-yl)amino]quinazolin-8-yl]amino]piperidin-1-yl]ethanone | non-polymer | 365.4 | 1 | Chemie (934) | |||
| 3 | AAA | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | AAA | 1-phenylurea | non-polymer | 136.2 | 1 | Chemie (PHU) | |||
| 5 | water | water | 18.0 | 373 | Chemie (HOH) |
Sequence modifications
AAA: 806 - 1124 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Met 798 | - | initiating methionine |
| Gly 799 | - | expression tag |
| His 800 | - | expression tag |
| His 801 | - | expression tag |
| His 802 | - | expression tag |
| His 803 | - | expression tag |
| His 804 | - | expression tag |
| His 805 | - | expression tag |
| Ser 1040 | Cys 1040 | conflict |
| Ser 1048 | Cys 1048 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37177.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 597.6 | |
| All* | Total formula weight | 37775.0 |
