7P7P
Crystal structure of ERAP2 aminopeptidase in complex with phosphinic pseudotripeptide((1R)-1-Amino-3-phenylpropyl){(2S)-3-[((2S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino]-2-{[3-(2-hydroxyphenyl)-isoxazol-5-yl]methyl}-3-oxopropyl}phosphinic acid
Summary for 7P7P
Entry DOI | 10.2210/pdb7p7p/pdb |
Related | 5AB0 5AB2 5CU5 |
Descriptor | Endoplasmic reticulum aminopeptidase 2, TRIETHYLENE GLYCOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (16 entities in total) |
Functional Keywords | erap2, transition state analogues, antigen presentation, hydrolase, phosphinic pseudotripeptides, aminopeptidase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 230750.79 |
Authors | Giastas, P.,Stratikos, E.,Mpakali, A. (deposition date: 2021-07-20, release date: 2022-01-26, Last modification date: 2024-01-31) |
Primary citation | Mpakali, A.,Georgiadis, D.,Stratikos, E.,Giastas, P. Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2. Acs Med.Chem.Lett., 13:218-224, 2022 Cited by PubMed: 35178178DOI: 10.1021/acsmedchemlett.1c00582 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report