7OVY
Crystal structure of a dimeric based inhibitor JG34 in complex with the MMP-12 catalytic domain
Summary for 7OVY
Entry DOI | 10.2210/pdb7ovy/pdb |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | hydrolase, hydrolase-inhibitor crystal complex, hydrolase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 19407.69 |
Authors | Ciccone, L.,Rossello, A.,Vera, L.,Nuti, E.,Stura, E.A. (deposition date: 2021-06-15, release date: 2021-10-27, Last modification date: 2024-01-31) |
Primary citation | Cuffaro, D.,Camodeca, C.,Tuccinardi, T.,Ciccone, L.,Bartsch, J.W.,Kellermann, T.,Cook, L.,Nuti, E.,Rossello, A. Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors. Acs Med.Chem.Lett., 12:1787-1793, 2021 Cited by PubMed: 35111280DOI: 10.1021/acsmedchemlett.1c00411 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.24 Å) |
Structure validation
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