7OR4
Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, B142
Summary for 7OR4
Entry DOI | 10.2210/pdb7or4/pdb |
Descriptor | Dipeptidyl peptidase 8, trimethylamine oxide, methyl 3-[4-[(4-bromophenyl)methyl]piperazin-1-yl]carbonyl-5-[(2-ethyl-2-methanoyl-butanoyl)amino]benzoate, ... (4 entities in total) |
Functional Keywords | dpp8, dpp9, 4-oxo-b-lactam, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 208233.85 |
Authors | |
Primary citation | Carvalho, L.A.R.,Ross, B.,Fehr, L.,Bolgi, O.,Wohrle, S.,Lum, K.M.,Podlesainski, D.,Vieira, A.C.,Kiefersauer, R.,Felix, R.,Rodrigues, T.,Lucas, S.D.,Gross, O.,Geiss-Friedlander, R.,Cravatt, B.F.,Huber, R.,Kaiser, M.,Moreira, R. Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9. Angew.Chem.Int.Ed.Engl., 61:e202210498-e202210498, 2022 Cited by PubMed: 36089535DOI: 10.1002/anie.202210498 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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