7OEM
Crystal structure of the human METTL3-METTL14 complex with compound UOZ120
Summary for 7OEM
Entry DOI | 10.2210/pdb7oem/pdb |
Descriptor | N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | mettl3, inhibitor, complex, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 62510.40 |
Authors | Bedi, R.K.,Huang, D.,Caflisch, A. (deposition date: 2021-05-03, release date: 2021-10-20, Last modification date: 2024-02-07) |
Primary citation | Bedi, R.K.,Huang, D.,Li, Y.,Caflisch, A. Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023 Cited by DOI: 10.1021/acsbiomedchemau.3c00023PDB entries with the same primary citation |
Experimental method |
Structure validation
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