7NZY

Crystal structure of human Casein Kinase I delta in complex with CGS-15943

Summary for 7NZY

• Entry DOI: 10.2210/pdb7nzy/pdb
• Descriptor: Casein kinase I isoform delta, 9-chloranyl-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine, MALONATE ION, ... (5 entities in total)
• Functional Keywords: kinase, inhibitor, complex, atp-competitive, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 147762.29

Authors

Pichlo, C.,Baumann, U. (deposition date: 2021-03-24, release date: 2022-10-05, Last modification date: 2024-01-31)

• Primary citation: Wesseler, F.,Lohmann, S.,Riege, D.,Halver, J.,Roth, A.,Pichlo, C.,Weber, S.,Takamiya, M.,Muller, E.,Ketzel, J.,Flegel, J.,Gihring, A.,Rastegar, S.,Bertrand, J.,Baumann, U.,Knippschild, U.,Peifer, C.,Sievers, S.,Waldmann, H.,Schade, D.; Phenotypic Discovery of Triazolo[1,5- c ]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype.; J.Med.Chem., 65:15263-15281, 2022; PubMed: 36346705; DOI: 10.1021/acs.jmedchem.2c01199

Experimental method

X-RAY DIFFRACTION (1.85 Å)