7NZY

Crystal structure of human Casein Kinase I delta in complex with CGS-15943

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Casein kinase I isoform delta	polymer	314	36457.9	4	UniProt (P48730) Pfam (PF00069)	Homo sapiens (Human)	CKI-delta,CKId,Tau-protein kinase CSNK1D
2	E, H, J, M (A, B, C, D)	9-chloranyl-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine	non-polymer		285.7	4	Chemie (UX2)
3	F, G, N, O (A, D)	MALONATE ION	non-polymer		102.0	4	Chemie (MLI)
4	I, K, L, P (B, C, D)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	663	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 294 (UniProt: P48730)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	145831.5
Non-Polymers*	Number of molecules	12
	Total formula weight	1930.8
All*	Total formula weight	147762.3

*Water molecules are not included.