7NQJ
C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-ethyl-2-(1-methyl-1H-1,2,3-triazol-4-yl)-6-(1-phenylethyl)isonicotinamide
Summary for 7NQJ
Entry DOI | 10.2210/pdb7nqj/pdb |
Related | 7NQ5 7NQ7 7NQ8 7NQ9 |
Descriptor | Bromodomain-containing protein 2, N-ethyl-2-(1-methyl-1H-1,2,3-triazol-4-yl)-6-(1-phenylethyl)isonicotinamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14060.19 |
Authors | Chung, C. (deposition date: 2021-03-01, release date: 2021-04-07, Last modification date: 2024-06-19) |
Primary citation | Aylott, H.E.,Atkinson, S.J.,Bamborough, P.,Bassil, A.,Chung, C.W.,Gordon, L.,Grandi, P.,Gray, J.R.J.,Harrison, L.A.,Hayhow, T.G.,Messenger, C.,Mitchell, D.,Phillipou, A.,Preston, A.,Prinjha, R.K.,Rianjongdee, F.,Rioja, I.,Seal, J.T.,Wall, I.D.,Watson, R.J.,Woolven, J.M.,Demont, E.H. Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. J.Med.Chem., 64:3249-3281, 2021 Cited by PubMed: 33662213DOI: 10.1021/acs.jmedchem.0c02156 PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)