7NDM
Crystal structure of the heterocyclic toxin methyltransferase from Mycobacterium tuberculosis with bound substrate 4-hydroxyisoquinolin-1(2H)-one
Summary for 7NDM
Entry DOI | 10.2210/pdb7ndm/pdb |
Descriptor | Heterocyclic toxin methyltransferase (Rv0560c), S-ADENOSYL-L-HOMOCYSTEINE, 4-oxidanyl-2~{H}-isoquinolin-1-one, ... (6 entities in total) |
Functional Keywords | methyltransferase, hqno-detoxification, sam-dependent, 1, 4-dihydroxyisoqunioline, transferase |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 1 |
Total formula weight | 27137.07 |
Authors | Denkhaus, L.,Sartor, P.,Einsle, O.,Gerhardt, S.,Fetzner, S. (deposition date: 2021-02-02, release date: 2021-09-22, Last modification date: 2024-01-31) |
Primary citation | Sartor, P.,Denkhaus, L.,Gerhardt, S.,Einsle, O.,Fetzner, S. Structural basis of O-methylation of (2-heptyl-)1-hydroxyquinolin-4(1H)-one and related compounds by the heterocyclic toxin methyltransferase Rv0560c of Mycobacterium tuberculosis. J.Struct.Biol., 213:107794-107794, 2021 Cited by PubMed: 34506908DOI: 10.1016/j.jsb.2021.107794 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
Download full validation report